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合乐888官方手机app·人类基因组编辑国际峰会组委会回应基因编辑婴儿事件

发布时间: 2020-01-09 13:45:20     人气: 677

合乐888官方手机app·人类基因组编辑国际峰会组委会回应基因编辑婴儿事件

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人类胚胎基因组编辑委员会 

大会组委会声明

在第二届人类基因组编辑国际峰会(香港)即将召开之际,大会组委会获悉,中国诞生了一对被胚胎基因组编辑的双胞胎,而领导这项研究的贺建奎研究员也即将在本次峰会(周三)上发言。

可遗传的基因组编辑临床试验,一直是许多研究小组争论和探讨的热点话题,目前已经有大量的研究证据,为进行可遗传的基因组编辑临床试验提供了有力的理论证据和研究基础。美国国家科学院、工程与医学科学院2017年发表的报告中写道,在临床前研究充分阐明潜在的风险和益处,并且通过同行评审的情况下,这类的临床研究可能会被批准。但这仅仅是在没有更有效的治疗手段情况下,人们选择更先进医学手段的方式,但不得不提到的是,这些研究提供的手段只是一类可以选择的替代方式,而在临床研究进行的整个过程中,必须要做到高度的透明化,并且需要经历严格的监督和审查。此外,报告还提到,在进行这类研究时,我们应该保持谨慎的态度,同时需要广泛征求社会公众的意见和建议,并且在相关部门制定了有效的监管手段(包括研究的标准和结构体系)的情况下,这项研究才是真正有意义和科学的。

让我们将目光放到欧洲。2018年英国纳菲尔德生物伦理学委员会发布了一份独立调查报告,这份报告明确指出“我们应该建立一个高效的遗传性基因组编辑的干预环境”,这样才能保证人类遗传基因编辑的安全性。而在中国,导致了这两个孩子出生的临床试验是否符合相关标准,还有待商榷。

大会组委会希望通过这次高峰论坛的对话,可以进一步增进全世界对人类基因组编辑相关研究问题和伦理问题的认识和理解,而我们的目标是确保人类基因组编辑安全、合理、有效且负责地进行,并且造福全社会。

联系方式:

莫莉·高尔文(Molly Galvin)

公共信息和新闻办公室

美国国科学院院,工程与医学院

电子邮箱:mgalvin@nas.edu

联系电话: +1-202-731-2841

声明原文如下:

Nov。 26, 2018

Statement from the Organizing Committee on Reported Human Embryo Genome Editing

HONG KONG -- On the eve of the Second International Summit on Human Genome Editing, we were informed of the birth of twins in China whose embryonic genomes had been edited。 The researcher who led the work, He Jainkui, is scheduled to speak at the summit on Wednesday。

The criteria under which heritable genome-editing clinical trials could be deemed permissible have been the subject of much debate and discussion by many research groups。 

Numerous studies have provided guidance for the conduct of heritable genome-editing clinical trials。 One such study, a 2017 report by the U.S。

National Academies of Sciences, Engineering, and Medicine, concluded that clinical trials might be permitted after peer-reviewed preclinical research further clarifies the potential risks and benefits, only for compelling medical reasons in the absence of reasonable alternatives, and with maximum transparency and strict oversight。  The report noted that such research should be approached with caution and with broad public input。 

It specified a regulatory framework that included ten recommended criteria and structures。 A second major report, released in 2018, which was the result of an independent inquiry by the Nuffield Council on Bioethics in the U.K。, also specifies “circumstances in which heritable genome editing interventions should be permitted。” 

Whether the clinical protocols that resulted in the births in China conformed with the guidance in these studies remains to be determined。

We hope that the dialogue at our summit further advances the world’s understanding of the issues surrounding human genome editing。 

Our goal is to help ensure that human genome editing research be pursued responsibly, for the benefit of all society。 

Contact:

Molly Galvin

Office of News and Public InformationU.S。 National Academies of Sciences, Engineering, and Medicine

mgalvin@nas.edu

Mobile: +1-202-731-2841

声明原文:http://www8.nationalacademies.org/onpinews/newsitem.aspx?RecordID=11262018

会议日程如下:

(贺建奎处高亮)

AGENDA

http://www.nationalacademies.org/hk/index.html

Tuesday, 27 November 2018

7:30 a.m。

Registration/LightBreakfast

8:30 a.m。

Welcome,Introductions, and Opening Remarks

Moderator:

Summit OrganizingCommittee Chair DavidBaltimore,* CaliforniaInstitute of Technology

Speech:

The Hon。 Mrs。 Carrie Lam, Chief Executive, Hong Kong SpecialAdministrative Region

Opening Remarks:

Lap-Chee Tsui, The Academy of Sciences of Hong Kong

John Skehel,* The Royal Society

Victor J。 Dzau, U.S。 National Academy of Medicine

9:00 a.m。

Genes, Genomes, andGenetic Variation

Moderator:

Kathryn Song Eng Cheah, The University of Hong Kong

Speakers:

John Christodoulou, The University of Melbourne

Pak C。 Sham, University of Hong Kong

Dana Carroll, University of Utah

10:00 a.m。

Discussion withAudience

10:30 a.m。

Break

11:00 a.m。

Social andPhilosophical Reflections on Manipulating Genetic Variation

Moderator:

Kazuto Kato,* Osaka University

Speakers:

Renzong Qiu, Chinese Academy of Social Science

Mohammed Ghaly, Hamad Bin Khalifa University

Maurizio Balistreri, Università degli Studi di Torino

Satoshi Kodama, Kyoto University

MargaretSleeboom-Faulkner, University of Sussex

12:30 p.m。

Discussion withAudience

1:00 p.m。

Lunch

2:00 p.m。

The Science of HumanGenome Editing

Moderator:

Duanqing Pei,* Guangzhou Institutes of Biomedicine andHealth

Speakers:

Feng Zhang, Broad Institute

David R。 Liu, Broad Institute

Angelo Lombardo, San Raffaele University

Jennifer Doudna,* University of California, Berkeley

3:15 p.m。

Discussion withAudience

3:45 p.m。

Break

4:15 p.m。

Update: GovernmentalActions and Advisory Opinions Regarding Human Genome Editing

Moderator:

Jennifer Merchant,* Université Panthéon-Assas Paris

Speakers:

Xiaomei Zhai,* Chinese Academy of Medical Sciences and Peking Union Medical College

Hervé Chneiweiss, Centre National de la RechercheScientifique, France

S。 R。 Rao, Ministry of Science and Technology,Government of India

Hidenori Akutsu, National Research Institute for Child Health and Development

Dianne Nicol, University of Tasmania

Tamra Maree Lysaght, National University of Singapore

Lot Chan, Hong Kong Special Administrative Region

6:00 pm

Discussion with Audience

6:30 pm

Adjourn

Wednesday, 28 November 2018

8:00 a.m。

Registration/LightBreakfast

8:30 a.m。

Welcome and Overview of Day’s Program

Summit OrganizingCommittee Chair David Baltimore,* CaliforniaInstitute of Technology

8:35 a.m。

Current Research and Clinical Applications: Pathways to Translation

Moderator:

Y。 M。 Dennis Lo, The Chinese University of Hong Kong

Speaker:

George Q。 Daley,* Harvard Medical School

9:00 a.m。

Discussion with Audience

9:20 a.m。

Blood Disorders –Basic and Translational Research

Moderator:

BeverleyFrancis-Gibson, Sickle Cell DiseaseAssociation of America, Inc。

Speakers:

Merlin Crossley, University of New South Wales, Sydney

Sivaprakash Ramalingam, Institute of Genomics and IntegrativeBiology

Matthew Porteus,* Stanford University

Junjiu Huang, Sun Yat-sen University

Vence L。 Bonham, National Human Genome Research Institute

10:35 a.m。

Discussion withAudience

11:00 a.m。

Break

11:30 a.m。

Human Embryo Editing

Moderator:

Robin-Lovell-Badge,* The Francis Crick Institute

Speakers:

Kathy Niakan, The Francis Crick Institute

Paula Amato, Oregon Health & Science University

Maria Jasin, Memorial Sloan Kettering Cancer Institute

Xingxu Huang, Shanghai Tech University

Jiankui He, Southern University ofScience and Technology

12:30 pm

Discussion with Audience

1:00 pm

Lunch

2:15 pm

Genome Editing ofHeritable Diseases: Technical and Societal Considerations

Moderator:

Richard O。 Hynes, Massachusetts Institute of Technology

Speakers:

Adrian Thrasher, University College London

R。 Rodney Howell, University of Miami

Charles A。 Gersbach, Duke University

Pauline McCormack, Newcastle University

3:15 pm

Discussion withAudience

3:45 pm

Break

4:15 pm

Human Genome Editing:Research Ethics

Moderator:

R。 Alta Charo,* University of Wisconsin, Madison

Speakers:

Bärbel Friedrich, German National Academy of SciencesLeopoldina

Andy Greenfield, Medical Research Council

Jeffrey Kahn, Johns Hopkins University

TetsuyaIshii, Hokkaido University

Eben Kirksey, Deakin University

5:30 pm

Discussion with Audience

6:00 pm

Adjourn

Thursday, 29 November 2018

7:30 a.m。

Registration/Light Breakfast

8:00 a.m。

Welcome and Overview of Day’s Program

Summit OrganizingCommittee Chair David Baltimore,* CaliforniaInstitute of Technology

8:10 a.m。

Global Perspectives: Somatic and Germline Therapy, Prevention, and Enhancement Applications

Moderator:

Ayo Wahlberg, University of Copenhagen

Speakers:

Kevin G。 Behrens, University of the Witwatersrand

Guido de Wert, Maastricht University

Peter Mills, Nuffield Council on Bioethics

Yuko Harayama, Tohoku University

9:10 a.m。

Discussion with Audience

9:30 a.m。

Identifying BasicPrinciples for Moving Forward

Moderator:

María de Jesús MedinaArellano, National AutonomousUniversity of Mexico

Speakers:

Sarah Chan, University of Edinburgh

Ames Dhai, University of the Witwatersrand

J。 Benjamin Hurlbut, Arizona State University

Ock-Joo Kim, Seoul National University

10:30 a.m。

Discussion with Audience

11:00 a.m。

Break

11:30 a.m。

Public Engagement Efforts

Moderator:

Jennifer Doudna,* University of California, Berkeley

Speakers:

Anna Middleton, Wellcome Sanger Institute

Joy Y。 Zhang, University of Kent

Megan Munsie, University of Melbourne

Masako Takuma, National Museum of Emerging Science andInnovation

12:15 pm

Discussion with Audience

12:45 pm

Concluding Remarks from the Organizing Committee

1:00 pm

Discussion with Audience

1:30 pm

Adjourn

*Member of Summit Organizing Committee

Second International Summit on Human Genome Editing Breakout Sessions

I。 Breakout Session on Embryo and GermlineEditing: A Forward Look at Research, Application, and Governance

Thursday, November 29, 20182:15-4:45 pmGrand Hall, Lee Shau Kee Lecture Centre, The University of Hong KongIn conjunction with the Second International Summit on Human Genome Editing, this breakout session will focus on the use of genome editing in human embryos and germline cells。 The session will provide an opportunity for a more in-depth discussion of the research presented during the summit, an opportunity to discuss other relevant research, and an opportunity to discuss the potential use of genome editing to make alterations that may be heritable。 The session will include presentations from local researchers as well as from researchers around the world。Light lunch will be available 45 minutes prior to this event。

AGENDA

Session Co-chairs:

Robin Lovell Badge,* The Francis Crick Institute

Duanqing Pei,* Guangzhou Institutes of Biomedicine andHealth

2:15-3:00 pm

Panel 1

Speakers:

Maria Jasin, Sloan Kettering Institute – Trust inScience, Scientists and the Role of Journals

Kathy Niakan, The Francis Crick Institute – The Unknowns of Early Human Development and the Impact on Genome Editing

Xingxu Huang, ShanghaiTech University: To DevelopBase-Editing Platforms for Correction of Pathogenic Mutations in Human Embryos

3:00-3:15 pm

Panel Discussion

3:15-4:00 pm

Panel 2

Speakers:

Jiankui He, Southern University of Science andTechnology – The Roadmap towards Developing Standards for Safety and Efficacy for Human Germline Gene Editing and Moral Principles

Helen O’Neill, University College London – Forging a Bench to Clinical Pipeline in Human Germline Editing

Judith Daar, University of California, Irvine School of Law – The Ethics of Germline Genome Editing: The Role of Consent Among theUnavailable and Unborn

4:00-4:15 pm

Panel Discussion

4:15-4:45 pm

Plenary Discussion

II。 Let’s Talk About Genomics and Genome Editing

Thursday, November 29, 20186:30-9:30 pmThe Wang Gungwu Lecture Hall, Graduate House, The University of Hong KongThis event is designed to provide members of the public with a generalintroduction to genomics and genome editing。 It will provide participants withan opportunity to consider scientific and ethical questions related to the useof genome editing and engage in a conversation with experts on these topics。The event will be simultaneously translated from English into Cantonese。Light refreshments will be provided。

AGENDA

6:30 pm

Registration and LightRefreshments

6:45 pm

Welcome

Victor J。 Dzau, President, U.S。 National Academy of Medicine

6:55 pm

Introduction to HumanGenomics

Speaker:

Clara Tang, The University of Hong Kong

7:20 pm

Introduction to GenomeEditing

Speaker:

Robin Lovell-Badge,* The Francis Crick Institute

7:50 pm

Break

8:00 pm

Public Engagement onBiosciences in China

Speaker:

Joy Zhang, University of Kent

8:20 pm

Public Engagement onHuman Genome Editing in the UK

Speaker:

Sarah Chan, The University of Edinburgh

8:40 pm

Audience Discussion ofHuman Genome Editing

9:30 pm Adjourn

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